Chief Professor of Qingdao University, Dean of School of Pharmacy, Doctoral Supervisor, Overseas Distinguished Expert of "Mount Taishan Scholar" of Shandong Provincial Government, Former Lifelong Professor and Doctoral Tutor of West Virginia University School of Medicine, President of China Association for Science and Technology in America (CAST-USA), Executive Vice Chairman of North American Pharmacology Branch of Chinese Pharmacological Society, and Standing Committee Member of Neuropsychopharmacology Professional Committee. Founder/Executive Director of the Association of Chinese Neuroscientists in the United States, Executive Director of the North American Pharmacological Society, and Honorary President of the West Virginia Chinese Association/West Virginia Branch of the Association for American Studies (CAST-WV). President of the Mount Taishan Academic Forum - International Neuropsychiatric Science Academic Summit (2017-2019).
He successively obtained a Bachelor's degree in Medicine from Southern Medical University (formerly the First Military Medical University) in 1987, a Master's degree in Pharmacology from the Academy of Military Medical Sciences in 1992, and a Ph.D. in Pharmacology in 1995. Postdoctoral fellow at Louisiana State University Center for Health Sciences and University of Tennessee Center for Health Sciences (1998-2002). Since 2005, he has served as an assistant professor, tenured associate professor, tenured full professor, and doctoral supervisor at the University of West Virginia School of Medicine.
Has won the NARAD Young Scientist Award twice (2006, 2008) in the United States. Published over 120 papers and reviews. I am the editor in chief of one English edition of a monograph on Phosphodiesterases (PDE) ("Phosphodiesterases: CNS Functions and Diseases", Springer Publishing Group, 2017), and have participated in the editing of five English edition PDE monographs.
Served as a review expert for various domestic and international funds/projects, including the NIH Research Fund (R01, R21, F series) in the United States, the Special Fund for Research on Elderly Dementia of the Florida Department of Health in the United States, the European Alzheimer's Disease Research Fund ISAO, key projects and major international cooperation projects of the National Natural Science Foundation of China, the "Changjiang Scholar Distinguished Professor/Lecture Professor" program of the Ministry of Education, and overseas peer review for promotion to senior professional titles in multiple prestigious universities in China. I am the deputy editor in chief or editorial board member of more than ten internationally renowned academic journals, including Frontiers in Pharmacy, Frontiers in Aging Neuroscience, Journal of Alzheimer's Disease, Metabolic Brain Disease, Neuroscience Bulletin, Austin Psychiatry, and General Psychiatry.
Main research directions:
The regulation and mechanism of phosphodiesterase (PDE) and cellular signaling pathways on central function and central nervous system diseases (including alcohol addiction, senile dementia such as Alzheimer's Disease, anxiety, depression, etc.), as well as treatment strategies.
Main research projects:
(1) General project of the National Natural Science Foundation of China: The regulatory effect of 4-type phosphodiesterase (PDE4) on drinking behavior and its intracellular signaling mechanism. 550000 yuan, ID: 81773717, project leader (2018-2021).
(2) The National Natural Science Foundation of China's general project focuses on the regulation and cellular signaling mechanism of 4-type phosphodiesterase in the comorbidity of Alzheimer's disease and depression. 550000 yuan, ID: 82073827, project leader (2021-2024).
Representative papers and monographs (no more than 5 in the past 5 years):
(1) Zhou Y, Xu B, Yu H, Zhao W, Song X, Liu Y, Wang K, Peacer N, Zhao X, Zhang HT * Biochanin A Attenuates Ovariectomy Induced Cognition Deficitvia Antioxidant Effects in Female Rates Front Pharmacol 2021 Mar 16; 12: 603316 Doi: 10.3389/fphar.2021.603316 PMID: 33815102; PMCID: PMC8010695
(2) Chen Y, Wang H, Wang WZ, Wang D, Skaggs K, Zhang HT * Phosphodiesterase 7 (PDE7): A unique bug target for central nervous system diseases Neurophysics July 7, 2021; 196:108694 Epub ahead of print. PMID: 34245775
(3) Wang H, Zhang FF, Xu Y, Fu HR, Dan Wan X, Wang L, Chen W, Xu XY, Gao YF, Zhang JG, Zhang HT * The pathosteroid rase-4 inhibitor biofilst, a potential treatment for the comorbidity of memory loss and depression in Alzheimer's disease: a preclinical study in APP/PS1 transgenic mice Int J Neuropsychharmacol 2020 Dec 10; 23 (10): 700-711 PMID: 32645141 PMCID: PMC7727475
(4) Pei Y, Davies J, Zhang M, Zhang HT * The role of syntactic dysfunction in Alzheimer's disease J Alzheimer's Dis 2020, May 14 76 (1): 49-62 Doi: 10.3233/JAD-191334 Epub ahead of print. PMID: 32417776
(5) Shi J, Liu HX, Pan JC, Chen J, Zhang NP, Liu KP, Fei N, O'Donnell JM, Zhang HT *, Xu Y * Introduction of photography 2 by Bay 60-7550 decreases ethanol intake and preference in mice Psychology (Berl) 2018, 235:2377-2385 PMID: 29876622